diff --git a/Doc/using/configure.rst b/Doc/using/configure.rst
index 0d420d80f8e261e..9f1b0c6a2a6607f 100644
--- a/Doc/using/configure.rst
+++ b/Doc/using/configure.rst
@@ -881,6 +881,17 @@ also be used to improve performance.
 
    See the ``PyDoc_STRVAR()`` macro.
 
+   .. note::
+
+      Disabling doc strings also means that :func:`inspect.signature` cannot
+      retrieve signatures for built-in functions and methods implemented in C,
+      since the signatures for these functions are embedded in their docstrings
+      (generated by `Argument Clinic
+      <https://devguide.python.org/development-tools/clinic/>`_). This may
+      affect tools and libraries that rely on introspecting built-in callables,
+      such as :func:`help` and some third-party frameworks.
+
+
 .. option:: --enable-profiling
 
    Enable C-level code profiling with ``gprof`` (disabled by default).