diff --git a/Doc/library/ctypes.rst b/Doc/library/ctypes.rst
index fb74e7f3ee37192..f0a934b15ceb2ab 100644
--- a/Doc/library/ctypes.rst
+++ b/Doc/library/ctypes.rst
@@ -1968,7 +1968,11 @@ See :ref:`ctypes-callback-functions` for examples.
 .. function:: PYFUNCTYPE(restype, *argtypes)
 
    The returned function prototype creates functions that use the Python calling
-   convention.  The function will *not* release the GIL during the call.
+   convention.  Unlike :func:`CFUNCTYPE` and :func:`WINFUNCTYPE`, ctypes does
+   *not* release the GIL before calling the foreign function, so the function
+   may safely use the Python C API. Note that this does not prevent the GIL
+   from being released *during* the call.
+
 
 Function prototypes created by these factory functions can be instantiated in
 different ways, depending on the type and number of the parameters in the call: